Archive for the ‘Diarrhoea’ Category

Mast Cell Activation Syndrome!

Friday, June 15th, 2018

 

Does histamine control your life?   Are you even aware that it might?  You might have MCAS!!

Much of this information comes from Dr Tania Dempsey and Dr Jill Carnahan in the States….  but it is a Syndrome worth thinking about if you’re simply not getting on top of your pain, allergies, nervous system stresses etc….  Many doctors in Australia are totally unaware of this condition.

What is Mast Cell Activation Syndrome?

Mast cells, a type of blood cell, play an important role in the body’s immune system. They reside in all body tissues and form part of the body’s initial defence system. Mast cells react to foreign bodies and injury by releasing a variety of potent chemical mediators, such as histamine, when activated. In a healthy person these chemicals will act beneficially to protect and heal the body, but in a person with MCAS these same chemicals are inappropriately triggered and released and have a negative effect on the body. Amongst the triggers are a variety of different foods, exercise, chemicals, fragrances and stress. Many sufferers struggle to identify their triggers and continue to discover new triggers for many years after diagnosis.

MCAS forms part of a spectrum of mast cell disorders involving proliferation and/or excessive sensitivity of mast cells, it has been identified since 2007. It features inappropriate mast cell activation with little or no increase in the number of mast cells, unlike in Mastocytosis*.  MCAS causes a wide range of unpleasant, sometimes debilitating, symptoms in any of the different systems of the body, frequently affecting several systems at the same time. The onset of MCAS is often sudden, affecting both children and adults, sometimes in family groups, mimicking many other conditions and presenting a wide-range of different symptoms that can be baffling for both the patient and their physician. Often there are no obvious clinical signs since MCAS confounds the anatomy-based structure underpinning the traditional diagnostic approach. Very often Mast Cell Activation Syndrome is hiding in plain sight.

Mastocystosis:  very rare and NOT what we’re talking about here…

Mastocytosis involves inappropriate mast cell activation AS WELL AS an increased number of mast cells. It is a rare but relatively well known mast cell disorder and is currently easier to diagnose than MCAS.

Mast Cell Activation Syndrome (MCAS): When Histamine Goes Haywire…

Mast cells are present in most tissues throughout the human body, especially connective tissue, skin, intestinal lining cardiovascular system, nervous system, and reproductive organs. They are part of the allergic response designed to protect us from threat and injury.  When the body is exposed to a perceived threat, the mast cells secrete chemical mediators, such as histamine, interleukins, prostaglandins, cytokines, chemokine and various other chemicals stored in the cytoplasm of the cell.  These chemical messengers produce both local and systemic effects, such as increased permeability of blood vessels (inflammation and swelling), contraction of smooth muscle (stomach cramps and heart palpitations), and increase mucous production (congestion, sneezing, etc).   Historically, we thought of mast cells only in relation to an allergic or anaphylactic response.  We now know they play a profound role in immune activation, development of autoimmunity and many other disorders, such as POTS (postural orthostatic tachycardia syndrome).  Sadly we are seeing a large increase in patients presenting with mast cell disorders and MCAS.  I believe it is in part do to the onslaught of more pervasive environmental toxins, moulds and chemicals.

Withouts mast cells, we would not be able to heal from a wound.  They protect us from injury and help the body to heal.  Unfortunately, overactive mast cells can cause a variety of serious symptoms.

Symptoms of overactive mast cells may include:

  • skin rashes/hives
  • swelling/oedema
  • flushing
  • asthma
  • itching
  • abdominal pain
  • nausea/vomiting
  • diarrhoea
  • wheezing
  • shortness of breath
  • heart palpitations
  • anxiety, difficulty concentrating
  • headaches
  • brain fog
  • low blood pressure
  • fatigue

Mast cell activation syndrome (MCAS) is a condition symptoms involving the skin, gastrointestinal, cardiovascular, respiratory, and neurologic systems. It can be classified into primary (clonal proliferation or mastocytosis), secondary (due to a specific stimulus), and idiopathic (no identifiable cause). Proposed criteria for the diagnosis of MCAS included episodic symptoms consistent with mast cell mediator release affecting two or more organ systems with hives, swelling, flushing, nausea, vomiting, diarrhea, abdominal pain, low blood pressure, fainting, heart palpitations, wheezing, red eyes, itching, and/or nasal congestion.  For a diagram of all of the varied symptoms histamine can cause, click here.

Triggers may be medications, foods, supplements, hormones, opioids, stressors (physical or emotional), cold temperature, heat, pressure, noxious odors, chemicals, insect bites, trauma or environmental toxins.

We commonly see mast cell activation syndromes associated with CIRS (chronic inflammatory response syndrome) in response to biotoxins, such as mould, inflammagens, and lyme-related toxins.

Low MSH and Mast Cell Disorders?

As mentioned above, we frequently see histamine intolerance and MCAS in patients with mold-related CIRS (chronic inflammatory response syndrome).  It is interesting to note that a common finding in CIRS is low MSH.  According to this study in the Journal of Investigative Dermatology, alpha-MSH plays an immunomodulatory role during inflammatory and allergic reactions of the skin.  In addition, there is evidence that MSH induces mast-cell apoptosis(cell death).

Definition of Mast Cell Activation Syndrome (MCAS)

  1. Typical clinical symptoms as listed above
  2. Increase in serum tryptase level or an increase in other mast cell derived mediators, such as histamine or prostaglandins (PGD2), or their urinary metabolites,
  3. Response of symptoms to treatment
Mast Cell Activation Syndrome (MCAS)

Mast cells can be activated by both direct and indirect mechanisms as a result of exposure of the host to pathogens.

Diseases Associated with Mast Cell Activation Syndrome (MCAS)

  • Allergies and Asthma
  • Autism
  • Autoimmune diseases (Hashimoto’s thyroiditis,  systemic lupus, multiple sclerosis, bullous pemphigoid, rheumatoid arthritis and others.Eczema
  • Celiac Disease
  • Chronic Fatigue Syndrome
  • CIRS (chronic inflammatory response syndrome)
  • Eosinophilic Esophagitis
  • Fibromyalgia
  • Food Allergy and Intolerances
  • Gastroesophageal reflux (GERD)
  • Infertility (mast cells in endometrium may contribute to endometriosis)
  • Interstitial Cystitis
  • Irritable Bowel Syndrome (IBS)
  • Migraine Headaches
  • Mood disorders – anxiety, depression, and insomnia
  • Multiple Chemical Sensitivities
  • POTS (postural orthostatic tachycardia syndrome)
Mast cells are known to be the primary responders in allergic reactions, orchestrating strong responses to minute amounts of allergens. Several recent observations indicate that they may also have a key role in coordinating the early phases of autoimmune diseases, particularly those involving auto-antibodies.

Mast cells are known to be the primary responders in allergic reactions, orchestrating strong responses to minute amounts of allergens. Several recent observations indicate that they may also have a key role in coordinating the early phases of autoimmune diseases, particularly those involving auto-antibodies.

Lab Tests for Mast Cell Activation Syndrome (MCAS) – many of these are as yet unavailable in Australia …  Possibly histamine is as yet the only available, but chat to Georgia about what our Naturopathic Labs can offer….

  • Lab tests specific to mast cell activation for suspected MCAS may include:
    • Serum tryptase (most famous mast cell mediator)
    • Serum chromogranin A
    • Plasma histamine
    • Plasma PGD2 (chilled)
    • Plasma heparin (chilled)
    • Urine for PGD2 (chilled)
    • PGF2a
    • N-methylhistamine
  • Tryptase is the most famous mast cell mediator. Serum tryptase value is usually normal in MCAS patients, but sometimes it is elevated.  Tryptase values that show an increase of 20% + 2 ng/ml above the baseline level are considered diagnostic for MCAS.
  • Chromogranin A is a heat-stable mast cell mediator.  High levels can suggest MCAS, but other sources must first be ruled out, such as heart failure, renal insufficiency, neuroendocrine tumors and proton pump inhibitor (PPI) use.
  • Heparin is a very sensitive and specific marker of mast cell activation.  However, due to its quick metabolism in the body, it is very difficult to measure reliably.
  • N-methylhistamine is usually measured in a 24 hour urine test to account for the variability in release over the course of the day.
  • Prostaglandin D2 is produced by several other cell types, but mast cell release is responsible for the dominant amount found in the body.  PGD2 is less stable than histamine and metabolized completely in 30 minutes.
  • Other less specific mast cell mediators that are sometimes abnormal in MCAS patients include Factor VIII, plasma free norepinephrine, tumor necrosis factor alpha, and interleukin-6.

Treatments to reduce MCAS symptoms and lower histamine

  • H1 Blockers
    1. hydroxyzine, doxepine, diphenhydramine, cetirizine, loratadine, fexofenadine
  • H2 Blockers
    1. Famotidine (Pepcid, Pepcid AC)
    2. Cimetidine (Tagamet, Tagamet HB)
    3. Ranitidine (Zantac)
  • Leukotriene inhibitors
    1. Montelukast (Singulair)
    2. Zafirlukast (Accolate)
  • Mast cell stabilizers –
    1. Cromolyn
    2. Ketotifen
    3. Hyroxyurea
  • Tyrosine kinase inhibitors – imatinib
  • Natural anti-histamines and mast-cell stabilizers
    • Ascorbic Acid
    • Quercetin
    • Vitamin B6 (pyridoxal-5-phosphate)
    • Omega-3 fatty acids (fish oil, krill oil)
    • Alpha Lipoic Acid
    • N-acetylcysteine (NAC)
    • Methylation donors (SAMe, B12, methyl-folate, riboflavin)
  • Certain probiotics decrease histamine production
    • Lactobacillus rhamnosus and bifidobacter species 
  • DAO Enzymes with meals – UmbrelluxDAO
  • Decrease consumption of high histamine foods (more on histamine-restricted diet)
    • Avoid alcoholic beverages
    • Avoid raw and cured sausage products such as salami.
    • Avoid processed or smoked fish products. Use freshly caught seafood instead.
    • Avoid pickles
    • Avoid citrus fruits.
    • Avoid chocolate
    • Avoid nuts
    • Avoid products made with yeast and yeast extracts
    • Avoid soy sauce and fermented soy products
    • Avoid black tea and instant coffee
    • Avoid aged cheese
    • Avoid spinach in large quantities
    • Avoid tomatoes, ketchup and tomato sauces
    • Avoid artificial food colorings & preservatives
    • Avoid certain spices: cinnamon, chili powder, cloves, anise, nutmeg, curry powder, cayenne pepper

References

  1. Mast Cell Activation Syndrome, A Review
  2. Mast cell activation disease: a concise practical guide for diagnostic workup and therapeutic options
  3. Presentation, Diagnosis and Management of Mast Cell Activation Syndrome by Dr. Afrin
  4. Histamine and Gut Immune Mucosal Regulation
  5. Dr. Theoharides presents “Mast Cell Disorders”
  6. Diagram of Histamine Symptoms
  7. Mast Cell Aware
  8. A Tale of Two Syndromes
  9. Mold Histamine Connection

Health issues and don’t know why? Is it leaky gut?!

Thursday, June 6th, 2013

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The healing journey with New Leaf

Saturday, March 2nd, 2013

Embarking on a health journey is a brave move to make. It means looking at the issues you may have avoided for a while and facing them head on. It’s a process that is often scary yet can also be richly rewarding. When you are the best version of yourself you can be, you can really shine and be there for those close to you.

It can be said that it’s a means of coming back to your basic self  – seeing your body as a precious temple and paying attention to what you really need. It’s treating yourself gently and gaining a greater connection to the whole of you – body and mind. As one of my favourite authors Sarah Avant Stover puts it – the only way out is in and through. To go through our health issues rather than going around them is the only real way to back to balance and health.

At New Leaf, we are committed to your success in this process. We know it’s yours, to go through in your way. Offering a harmonious range of therapies, we seek to find the real cause of your health issues and guide you back to balance and health.

We see your journey to optimal health as a partnership between yourself and us. Thus, we have a few suggestions for you in order that you get the best results from your treatment with us:

  • Eat a fresh, wholefoods diet. When you eat fresh, vital food, you feel just that. Everything we eat nourishes our cells. If we consider that the body is really the only vessel we have to take us through this lifetime, it makes sense to nourish it with the best food possible.
  • Drink a minimum of 2 litres of pure filtered water daily. Besides hydration, there are countless benefits of drinking adequate pure water. Improved energy, detoxification, digestion, skin condition and weight loss are just a few.
  • Limit caffeine, or better still, cut it altogether. Caffeine creates extra work for your liver, and can place stress on the adrenal glands and nervous system. It also promotes dehydration and in the long term, fatigue. There are many delicious herbal teas and coffee alternatives available in supermarkets and health food stores.
  • Sleep 8 hours a night. While sleeping as little as possible in modern society is often considered admirable behaviour, the truth is, it promotes premature aging, weight gain, can increase stress and complicate many other health issues. It may require changing your usual routine a little, but getting 8 hours of quality sleep a night is an investment in your health.
  • Spend a few minutes a day alone, doing some quiet breath awareness in a comfortable seated position. All you need do is focus on your breath with your eyes closed. This can have wonderfully beneficial effects on your nervous system, improving mood, reducing stress and creating calm. A calm body heals well!
  • Increase body movement. This means different things to different people. Start with where you are at in terms of your current physical fitness, and do what feels right for you. Even if it just means adding incidental exercise by taking the stairs instead of the lift, walking to a colleague’s desk rather than emailing, or taking a short walk before or after work. Start where you are at the moment and build gently from there.

These are simple steps you can take today to improve your body’s ability to balance and heal. You can do one at a time, a few, or all of them, whatever feels right and good for you. It’s up to you.

We look forward to supporting you in achieving a state of greater health.

New Leaf now provides Chi Nei Tsang Abdominal Massage – read on!

Tuesday, January 8th, 2013

Chi Nei Tsang (Abdominal Massage) available at New Leaf Natural Therapies

What is Chi Nei Tsang?

Energetically – who knows the cause of sickness?  Where does internal pain, issues with our major organs such as the liver and kidneys, the stomach, small intestines, large intestines come from?  Naturopathically, it has always been taught that step one for any long-term health problem has been to cleanse the body’s filters – the digestive tract, the liver, the immune system/lymphatic systems and the kidneys.  Congestion in any of these areas can cause poor energy, poor circulation and poor detoxification of any of these systems.

In Chinese medicine it has always been taught that blocked energy starts this toxicity building up – Chi Nei Tsang helps with both – it starts to move the inflammation, the toxicity and the energy blockages that are stopping blood, lymphatic flow and nutrient absorption throughout our major organs.

Have you ever felt ‘knots’ in your stomach, tightness under the ribs, described this to your therapist who simply prescribed antacids or digestive enzymes?  These is so much more to health than that…and the last thing you want is to suppress symptoms which may come back to haunt you down the track.

Our Foundations of Health programme is a nine month detoxification process which starts the body healing as our filters start to clear.  It is a long process (quick and dirty detoxes rarely make lasting change) to health for some people.

I found this fabulous description on Chi Nei Tsang from http://radiantliving.com/chi-nei-tsang-abdominal-massage/ in the U.S. and it describes energy and the abdomen and how it relates to our health, our wellbeing, our stressors, our operations and medications…

“The Taoist sages of ancient China observed that humans often develop energy blockages in their internal organs that result in knots and tangles in their abdomens. These obstructions occur at the center of the body’s vital functions and constrict the flow of Chi (energy), our life-force. The negative emotions of fear, anger, anxiety, depression, and worry cause the most damage. Problems can also be caused by overwork, stress, accidents, surgery, drugs, toxins, poor food, and bad posture.

Through meditative practices the sages learned to look within themselves. They discovered the internal organs connect with the Five Forces of the Universe and provide a link between the human microcosm and the universal macrocosm. The organs contain the essences of the spiritual force of a human being. They also provide the physical lines of force that hold the body together and give it structure.

When obstructed the internal organs store unhealthy energies that can overflow into other bodily systems and surface as negative emotions and sickness. Always in search of an outlet, these negative emotions and toxic energies create a perpetual cycle of negativity and stress. (Fig. 1) If the negative emotions can’t find an outlet, they fester in the organs or move into the abdomen, the body’s “garbage dump.” The abdomen can process some emotional garbage, but more often it can’t keep up with the flow. The energetic center of the body located at the navel becomes congested and cut off from the rest of the body.

Fig. 1 Negative energy cycle leads to knots and tangles in the abdomen.

B. Chi Nei Tsang: A Method to Clear Blocked Energy

Chi, the life-force energy, moves through the body’s internal channels, nervous system, blood vessels, and lymph glands. These systems concentrate and cross paths in the abdomen which acts as their control center. Tensions, worries, and stresses of the day, month, or year accumulate there and are seldom dispersed. ‘These disturbances can cause physical tangling and knotting of the nerves, blood vessels, and lymph nodes. The result is the gradual obstruction of energy circulation.

The ancient Taoists realized that negative emotions cause serious damage to one’s health, impairing both physical and spiritual functions. They understood that each human emotion is an expression of energy and that certain emotions could indicate the negative energy behind many physical ailments. They also identified a specific cycle of relationships between the emotions and the organs. For example, the experience of a “knot” in one’s stomach indicated the presence of worry, the negative emotion that accumulates in the stomach and spleen.
The Taoists discovered that most maladies could be healed once the underlying toxins and negative forces were released from the body. They developed the art of Chi Nei Tsang to recycle and transform negative energies that obstruct the internal organs and cause knots in the abdomen. Chi Nei Tsang clears out the toxins, bad emotions, and excessive heat or heat deficiencies-that cause the organs to dysfunction. (Fig. 2)

 

Fig. 2 Ancient Taoists massaged their abdomens and organs to stay healthy.
C. Chi Nei Tsang: A Complement to other Disciplines”

Makes a little sense doesn’t it?

We complement Chi Nei Tsang with all of the other services we provide in our clinic, in Wynnum Brisbane.

We know that Chi Nei Tsang is very energizing, strengthening, and detoxifying the internal organ systems of our body.  It supports the removal of negative influences and is fantastic for intestinal blockages, cramps, knots, lumps, scarring, headaces, menstrual cramps, poor blood circulation, back pain, infertility, impotence and many other issues.

Imagine avoiding intestinal surgery through an incredibly systematic and thorough treatment process.

For bookings, phone 3348 6098 and chat to Linda, Annette or Gabby to discuss pricing options.

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Hear us on 4BC & Bay FM:

Madonna Guy speaks at 9pm on 4BC (1116am) on Thursday nights with Walter Williams and Jason Jackson, and

Madonna also chats on Bay FM (100.3fm) with Doug and Laraine at 9.10am Friday mornings.

HCG: Diarrhoea on HCG

Saturday, November 24th, 2012
Diarrhoea on HCG:  not too common, but happens occasionally.
Why would HCG create diarrhoea??  Well, a couple of things that we’ve found:
1.  HCG may stimulte gall bladder function (because we’re releasing so much fat daily) – bile is a natural laxative;
2.  Releasing fungus and candida from the intestines (because we’re eating cleanly, we sometimes detox automatically) – fungus and candida love living in a sweet, acidic environment.  We’re also eating so many vegetables that for some lucky people they are working on detoxification processes with the natural ‘broom’ through the intestines…
3. Detoxification of heavy metals, drug residue, pesticides, stress toxins – fat tissue stores toxins.  Because we are releasing so much brown fat during HCG, we are releasing toxins of many types of nutrients and toxins into the bloodstream.  Depending on how nasty the toxins are we can feel dodgy (stressed, tired, nauseus, unwell, wired) and how much nutrition is stored (iron, B12, folate etc) we can feel amazingly energised on HCG.  Sometimes these toxins are so nasty our body will do anything in it’s power to release them from our bodies.  Diarrhoea is a small price to pay for this process!!
Things to do:
Liver and Gall Bladder Function:  Lipogen 1-2 tablets per meal
Diarrhoea Specific Gut Flora:  Ultra Flora SB Dysbiosis 2-6 daily depending on how bad the diarrhoea is
Bactrex, Costat and Parex:  Supports killing bacteria, parasites, candida and fungus.
Ultra Probioplex:  When we’re killing off bacteria, parasites, candida and fungus it creates inflammation.
Ultra Probioplex is one of the supplements that helps to ‘sop up’ the inflammation caused by killing these bugs!
Detoxification Processes:  Waiora NCD, Oxidant Protection, Meta B Complex, Silymarin…
Resetting your valves:  Kinesiology ‘ NOT ‘ technique (which we do at the clinic) is a process which  boosts digestive and liver function, resets your digestive valves, and finds reasons for the valves being dysfunctional…
Good luck!
Madonna Guy ND
New Leaf Natural Therapies
07 3348 6098
healthteam@nlnt.com.au
Facebook:  NewLeafNaturalTherapies   AND   HCG Weight Loss Support Group