Posts Tagged ‘gut flora’

What is the Role of Th1 and Th2 cells in Autoimmune Disease?

Thursday, September 19th, 2013

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What is the Role of Th1 and Th2 in Autoimmune Disease?

This article was originally written as a guest post for The Paleo Mom

FROM NEW LEAF:  This is a fantastically written article about T Helper 1 & 2 cells and how Auto-Immune is linked, which disorders are considered T Helper 1 or 2 dominant.  All of which we treat at New Leaf Natural Therapies. 

Those that suffer from autoimmune disease commonly experience symptoms that stem from imbalances within the functioning of their immune system. There are many factors that can influence this balance – stress, nutrition, vitamin and mineral deficiencies, gut flora, and allergies, among others. This way of looking at autoimmune disease is a growing trend in the alternative field, highlighted through the work of Datis Kharrazian.

What are Th1 and Th2?

T-helper cells (abbreviated as Th) are a vital part of the immune system. They are lymphocytes (types of white blood cells) that recognize foreign pathogens, or in the case of autoimmune disease, normal tissue. In response to this recognition, they produce cytokines, which are hormonal messenger proteins that are responsible for the biological effects of the immune system. They are divided into subgroups as follows:

Th1: Th1 cells are involved in what is called “cell-mediated” immunity, which usually deals with infections by viruses and certain bacteria. They are the body’s first line of defense against pathogens that get inside our cells. They tend to be pro-inflammatory and are involved in the development of organ-specific autoimmune disease.

Th2: Th2 cells are involved in what is called “humoral-mediated” immunity, which deals with bacteria, toxins, and allergens. They are responsible for stimulating the production of antibodies in response to extracellular pathogens (those found in blood or other body fluids). They tend not to be inflammatory and are involved in systemic autoimmune disease and other chronic conditions.

In a well-functioning immune system, both groups of these T helper cells work together to keep the system balanced. One side might become more active to eradicate a threat, then settling back to a balanced level.

How does this affect autoimmune disease?

In some people with autoimmune disease, patterns showing a dominance to either the Th1 or Th2 pathway have been shown. Although there are exceptions, the following table shows the conditions that are most commonly associated with a Th1 or Th2 dominant state:

TH1 dominant conditions:

Type I diabetes Multiple sclerosis Hashimoto’s Thyroiditis Grave’s Disease Crohn’s Disease Psoriasis Sjoren’s Syndrome Celiac Disease Lichen Planus Rheumatoid Arthritis Chronic viral infections

TH2 dominant conditions: 

Lupus Allergic Dermatitis Scleroderma Atopic Eczema Sinusitis Inflammatory Bowel Disease Asthma Allergies Cancer Ulcerative Colitis Multiple chemical sensitivity

When the th1 cells of the immune system are overactive, they can suppress the activity of th2 and vice versa. This can be problematic because these two components of the immune system function in a delicately balanced relationship. In the case of autoimmune disease, imbalance can further the attack on healthy tissue, thereby worsening symptoms.

Although research can lump those with certain conditions under the Th1/2 categories, in reality they can be all over the map. For instance, although most Hashimoto’s patients present a Th1 dominance, some can be Th2. It is also possible to have both Th1 and Th2 simultaneously overactive or under-active. Pregnancy can shift the immune system temporarily to Th2, which is why a lot of women find out they have Hashimoto’s after they give birth and their immune system returns to Th1 dominance.

How do I find out if I am Th1 or Th2 dominant?

AT New Leaf we provide Live Blood Screenings from which we do a white blood cell count – the count of neutrophils, lymphocytes and monocytes, along with eosinophils, let us know a huge amount about your immune system.

There are effective treatments, supplements, processes we use that can help to start the process of regulating your immune system.

Ask about:

  • kinesiology for the immune system (NOT)
  • kinesiology for finding out if your body is recognising foods, supplements, viruses, bacteria
  • live blood screenings
  • remedial massage and microcurrent for pain

3348 6098

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